声明
ABSTRACT
摘要
TABLE OF CONTENTS
Chapter 1 General Introduction
1.1 Chemical composition and basic structure of DNA
1.2 DNA nanotechnology
1.2.1 Structural DNA nanotechnology
1.2.2 Dynamic DNA nanotechnology
1.3 General methods for detection of single-base changes
1.3.1 High-temperature and chemical denaturation
1.3.2 Molecular beacon
1.3.3 Colorimetric sensor
1.3.4 Strand displacement
1.4 DNA sensors
1.4.1 FRET
1.4.2 SPR
1.4.3 QCM
1.4.4 Strand displacement on the QCM platform
1.5 Spherical nucleic acids
Chapter 2 Tuning the dynamics of DNA assembly on QCM platform
2.1 Introduction
2.2 Materials and Methods
2.3 Results and Discussions
2.4 Conclusions
Chapter 3 A Smart DNA-Gold Nanoparticle Probe for Detecting Single-base Changes on the Platform of Quartz Crystal Microbalance
3.1 Introduction
3.2 Materials and Methods
3.3 Results and Discussions
3.4 Conclusions
Chapter 4 By Means of Spherical Nucleic Acids,Discovery of an Unusual Degradation Behavior
4.1 Introduction
4.2 Materials and Methods
4.3 Results and Discussions
4.4 Conclusions
Chapter 5 Delivery and releasing of microRNA-34a into MCF-7 breast cancer cell by using spherical nucleic acid nanocarriers
5.1 Introduction
5.2 Materials and Methods
5.3 Results and Discussions
5.4 Conclusions
REFERENCES
附录
ACKNOWLEDGEMENTS
在读期间发表的学术论文与取得的其他研究成果