Improvement of Drug-Associated Acute Interstitial Nephritis by Corticosteroids

摘要

Objective: To explore the effect of corticosteroids on Drug-Induced Acute InterstitialNephritis (AIN).
　　Methods: A retrospective analysis of 98 patients with AIN mediated by drugsadmitted at the 1st Affiliated Hospital of Chongqing Medical University, China.Thepatients are divided into 2 groups (treated group 1 and control group 2) with 49 caseseach.According to their age, each group is divided into 3 age-groups (18-40, 40-60 and＞60 years) denominated A, B and C respectively.After admission, the two groups ofpatients were treated with diuretics, nutrition support therapy, correcting thehydro-electrolytic disorder or maintaining the acid-base balance and other symptomatictreatment.Besides these therapies, patients in treated group 1 received the therapy ofsteroids.The main clinical presentation, and blood and urinary analysis on the first dayof admission, the first, second, 12th and 24th week were collected.
　　Results: Improvement in Urea (BUN) and Creatinine (Cr) level as well as other signsand symptoms in treated group 1 was quicker than that in the control group 2.Out of the49 patients in the treated group 1, only 2 developed CRF after 24 weeks, while 6patients in the control group ended into CRF for the same period of time.The prognosisof old AKI patients (with age ＞ 60years old) in both treated and control groups waspoorer than that of the young and mid-aged patients.However, steroid treatment still tookeffect for the old patients.
　　Conclusion: Most of the AIN patients treated without steroids may still recover tonormal.However, steroids help renal function to recover quickly, and the treatment maybenefit to maintain a good short-term as well as a long-term prognosis for AIN patients.

目录

声明

TABLE OF CONTENTS

ABBREVIATIONS

ABSTRACT

BACKGROUND AND INTRODUCTION

PATIENTS AND METHODS

Patients and Groups

Renal biopsy and pathological findings

Treatment

Data Collection

Statistical Analysis

RESULTS

Improvement of clinical symptoms in AIN patients treated with corticosteroids

The speed of improvement in kidney function by corticosteroids for AKI patient

Effect od age renal function recovery of AKI patients treated witn corticosteroids

DISCUSSION

References

ACKNOWLEDGEMENTS

CERTIFICATE