EFFECT OF RESISTANT STARCH FILM PROPERTIES ON THE COLON-TARGETING RELEASE OF DRUG FROM COATED PELLETS

摘要

Resistant starch (RS) films were designed to target a protein to the colon by exploiting the colonic microbiota fermentative capacity. The RS films were coated to pellets and their mechanical resistance to the shear forces and the hydrostatic pressure within the pellets were investigated after contact with the gastrointestinal tract (GIT). In vitro tests showed that desired colon-targeted drug release can easily be obtained through controlling the proper relationship between enzymatic resistance and mechanical properties of RS film.