A wireless and batteryless 130mg 300µW 10b implantable blood-pressure-sensing microsystem for real-time genetically engineered mice monitoring

摘要

In this paper, we present the design, implementation, and in vivo evaluation results of a wireless, batteryless, less-invasive, implantable blood-pressure-sensing microsystem for real-time monitoring of genetically engineered mice. The microsystem merges MEMS technology and low-power CMOS integrated circuit design through a high level of system integration, together with a conventional molding-based packaging technique. The implanted microsystem, consisting of a blood-pressure-monitoring unit interfaced with a low-power ASIC, can detect the blood pressure inside a vessel and wirelessly transmit the information to a nearby receiver, while using adaptive RF powering to ensure a stable system power supply. The system employs an instrumented elastic sensing cuff made of bio-compatible silicone by using a conventional molding process.