Enhancing Mechanical Properties of Fibrin Matrices for Wound Healing Applications through Optimized B-knob Engagement

摘要

The observed changes in fibrin network structure and mechanical properties are specific to inclusion of the PEGylated 'B' knob peptide mimic and is concentration dependent, with significant differences observed when concentrations are above the dissociation constant. Future studies will characterize cellular responses to fibrin clots modified with high concentrations of PEGylated 'B' knob peptides through in vitro angiogenesis assays.