Intracortical Electrodes of Different Material, Shape, Size and Tethering Induce Differential Inflammatory Responses that Significantly Impact Chronic Electrode Function.

摘要

Histological analysis of tissue surrounding intracortical electrode implants revealed few significant differences indicating that it is capable of identifying only gross differences and not subtle differences that can explain the differential functional behavior of electrodes. Cytokine array analysis provided a quantitative assessment of inflammatory and neurotoxic cytokines prevailing in the milieu surrounding intracortical electrode implants temporally. Results from these assays indicate that expression levels of pro-inflammatory ILs and TNF family members could serve as markers to predict intracortical electrode performance chronically.