Surface-functionalized Polymer Microparticles for Combinatorial Delivery of Nucleic Acid Vaccines against Cancer

摘要

In conclusion we have developed a cationic microparticle formulation that can (a) deliver multiple therapeutic molecules (nucleic acids or proteins and peptides) in a single platform (b) efficiently transfect and activate (i.e. induces maturation) antigen presenting cells and (c) significantly enhance tumor survival in a murine model of B cell lymphoma. Such a formulation could offer a more relevant parenteral delivery option for a wide range of immunotherapy against cancer and infectious diseases.