Studies on the Formation of Biomimetic Apatite Layers on 3D-Printed Biodegradable Polymeric Scaffolds: Effect of Different Dynamic Coating Routes

摘要

By using different biomimetic environments it was possible to effectively coat a bone-like apatite layer on newly developed SPCL scaffolds. Dynamic conditions, besides mimicking better the biological milieu, allowed to obtain more stable apatite layers that can better follow the contour of the scaffold complex morphology. The circulating flow perfusion condition has proved to be advantageous over agitation one, since in the later case a higher degradation of the substrate was observed.