Novel Albumin Self-Assembled Liposomes for Drug Delivery Applications

摘要

Our studies reveal that the DIC is covalently immobilized onto the PVA polymeric chains. This allows the ligand to expose its albumin binding domain to the exterior. The bound albumin shows least conformational change. Albumin forms a continuous self assembled coat over the liposome surface. We hypothesize here that such a system can effectively prolong the circulation time of these colloidal particles, due to the non- opsonizing nature of the self- assembled albumin in its native conformation.