Sonic Hedgehog Signaling Pathway in Poly(Methacrylic Acid-co-Methyl Methacrylate)-Mediated Angiogenesis

摘要

In the wound healing study, MAA treatment increased vessel density in the granulation tissue and Shh+ cell density in the tissue surrounding the wound bed. Differential gene expression analysis demonstrated that MAA increased expression of Shh, Ptchl and downstream transcription factors Gli1, Gli2 and Gli3 suggesting activation of the Shh signaling pathway and its involvement in MAA-induced angiogenesis. Upregulation of Shh gene in SKPs in vitro in presence of MAA beads suggested that SKPs could be a potential source of Shh gene upregulation in vivo. Further research is required to identify to what extent Shh pathway activation is essential to MAA-induced angiogenesis.