Biopsy applications of Ti50Ni41Cu9 shape memory films for wireless capsule endoscope




Wireless capsule endoscopy (WCE) is a new technology to evaluate the patient with obscure gastrointestinal bleeding. However, there is still some deficiency existing in the current WCE, for example, lack of ability to biopsy and precisely locate the pathology. This study aimed to prepare and characterize TiNiCu shape memory alloy thin films for developing microgripper for biopsy (tissue sampling and tagging) applications. Ti50Ni41Cu9 thin films were prepared by co-sputtering of TiNi and Cu targets, and their transformation temperatures were slightly above that of human body. Results from differential scanning calorimetry, in-situ X-ray diffraction, curvature and electrical resistance measurement revealed clearly martensitic transformation of the deposited TiNiCu films upon heating and cooling. The biocompatibility of the TiNiCu films in the simulated gastric and intestinal solutions was also studied. Results showed the release of Ni and Cu ions is much less than the toxic level and the film did not lose shape memory effect even after 10-day immersion in the simulated solutions. TiNiCu/Si micro-cantilevers with and without electrodes were fabricated using the conventional micromachining methods and apparent shape memory effect upon heating and cooling was demonstrated.
机译:无线胶囊内窥镜检查(WCE)是一种新技术,可以评估患有消化道出血的患者。但是,当前的WCE中仍然存在一些缺陷,例如,缺乏活检和精确定位病理的能力。这项研究旨在准备和表征TiNiCu形状记忆合金薄膜,以开发用于活检(组织采样和标记)应用的微抓钳。通过共溅射TiNi和Cu靶制备Ti50Ni41Cu9薄膜,其转变温度略高于人体。差示扫描量热法,原位X射线衍射,曲率和电阻测量的结果表明,加热和冷却后,沉积的TiNiCu膜明显发生了马氏体转变。还研究了TiNiCu膜在模拟的胃液和肠液中的生物相容性。结果表明,Ni和Cu离子的释放远低于毒性水平,即使将膜浸入模拟溶液中10天,该膜也不会失去形状记忆效果。使用常规的微加工方法制造了带电极和不带电极的TiNiCu / Si微悬臂,并展示了加热和冷却时的明显形状记忆效果。



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