Developmental Trend Derived from Modules of Wnt Signaling Pathways

摘要

In this paper, we deal with the idea of creating a developmental trend from Wnt signaling pathways of different species. Wnt signaling pathway is involved in many crucial biological processes including from early embryonic development to stem cell management at later stages. The pathway varies in topology and size for each species that gets reflected in its modules. A comparison among species-specific pathways, taking into account the modules and pathway structure (in terms of nodes and edges) will throw light on crucial turning points in the development of Wnt signaling pathway. Hence, 31 species-specific Wnt signaling pathways have been modularized by the Modularization algorithm already developed by the authors. The modules were compared among themselves to find the trend of development. The trend established conserved modules among these pathways.