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Microfluidic system for coating micro-nanoparticles in view of pharmaceutical applications

机译:鉴于药物应用,用于涂覆纳米微粒的微流体系统

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This paper presents a micromachined fluidic chip and a fluidic system for the production of coated nano assembled microparticles. The chip, manufactured in silicon and glass, is designed to work by fluidic focussing and droplet formation [1-4]. The droplet formation and coating process are investigated by optical and fluorescence microscopy. After the evaporation of the solvents, the resulting microparticles and their structure are analysed in a confocal microscope, showing that round and fully coated microparticles were produced. The core particles and coating chosen for the experiments may both be loaded with different therapeutic agents. Therefore, the current approach provides as a model system towards the microfluidic realisation of particles for drug co-delivery [5]
机译:本文介绍了一种微加工的流体芯片和流体系统,用于生产包覆的纳米组装的微粒。该芯片由硅和玻璃制成,旨在通过流体聚焦和液滴形成来工作[1-4]。通过光学和荧光显微镜研究液滴的形成和涂覆过程。蒸发溶剂后,在共聚焦显微镜下分析所得的微粒及其结构,表明产生了圆形且被完全涂覆的微粒。为实验选择的核心颗粒和涂层都可以装载不同的治疗剂。因此,目前的方法提供了一种模型化系统,可实现药物共递送颗粒的微流控实现[5]

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