Genetic Epidemiology of Porcine Transmissible Gastroenteritis Virus Based on Whole Genome and S Gene Sequences

摘要

Porcine transmissible gastroenteritis virus (TGEV) is a pathogenic agent responsible for high diarrhea-associated morbidity and mortality in suckling piglets. To understand the genomic characteristics and evolutionary trend of TGEV during nearly 70 years, we reanalyzed published TGEV whole genome sequences. The genomic sequences of 40 strains from different sources were downloaded from National Center for Biotechnology Information. The phylogenetic analysis was performed using both whole genome sequences and S gene sequences. The regional distribution of TGEV virus was obvious while the time distribution was relatively scattered. In the whole genome sequences, 2505 variable sites were found and 56% of them occurred more than once. In S gene sequences, 505 variable sites were detected, which generated 191 amino acid mutations.