(Keynote) Biomimetic Preservation of Protein and Cell Surface Markers with Metal-Organic Frameworks for Controlled Protein Delivery and Room Temperature Storage and Shipping

摘要

Biological specimines from histology, protein-based therapeutics, and many biomacromolecules are unstable at room temperature. This instability necessitates considerable infrastructure be in place to allow the spoilage-free transportation of a number of important medicines including vaccines, insulin, antibody-based therapeutics, etc. This cold-chain infrastructure can increase the cost of these drugs by as much as 80%. Further to these problems, the instability of protein-based materials time-delayed or slow release formulations difficult. I will present a general method to "biomimetically" encarceate biomacromolecular assemblies into crystalline thermodynamically stable crystalline frameworks that readily dissolve in vivo to release intact and natively folded proteins. I will discuss strategies to incorporate these into prosthetics and implants for long-term delivery with a focus toward methodology in improving patient compliance with drugs and patient outcomes following prosthetic implants.