Raman spectroscopic characterization of anti-diabetic drug metformin hydrochloride

摘要

Raman scattering spectra of metformin hydrochloride, one of the most widely used oral anti-diabetic drugs which also possesses anti-aging and anti-tumor properties, have been obtained by high-resolution and high-sensitivity Raman-scattering technique. It is established that rather narrow (4-10 cm~(-1)) spectral lines of molecular vibrations are observed in of the metformin hydrochloride pressed powder sample in the important spectral range of 50-1700 cm~(-1). These "fingerprints" can be applied to reveal which chemical bonds produce spectral components corresponding to the vibrations of particular functional groups and the presence of crystalline state of the metformin hydrochloride without evidence of an amorphous phase. This observation makes the metformin hydrochloride as promising model system for development and application as molecular biosensors.