Gallstones:Chemical and Amino Acid Composition

摘要

The chemical and amino acid composition of gallstones of cholesterol,mixed(cholesterol + mineral component(calcium carbonate,calcium phosphate)),and pigment types was studied.The Mann-Whitney test revealed statistically significant differences in the levels of chemical elements and amino acids in the three types of gallstones studied.All types of gallstones in pairs were found to differ only in the content of the Ala,He,Leu,Pro,Phe,Asp and Glu amino acids.When comparing the pairs of gallstone types separately,it was revealed that cholesterol gallstones were statistically significantly different(p<0.05)from cholesterol gallstones with a mineral component(phosphate,carbonate)in the content of Ca,Mg,Mn,Zr,and Ala,Val,Gly,Ile,Leu,Pro,Asp,Phe,and Glu amino acids.In pigment gallstones,the content of Na,Cu,Fe,Tl,Zn and Mo was statistically significantly different from both types of cholesterol gallstones.The revealed differences in the chemical and amino acid compositions indicate different conditions for the formation of cholesterol,mixed,and pigment types of gallstones.