Cell Death Induction of Cancer Cells by Cyclometalated Iridium(III) Complex-Peptide Hybrids and Mechanism

摘要

Cationic amphiphilic peptides (CAPs) have received considerable attention as reagents for nonviral gene delivery, the treatment of cancer therapy and related diseases. It is generally considered that interactions of cationic amphiphilic molecules with cancer cell membranes explain their anticancer actions. However, the mechanisms responsible for the cationic amphiphile-induced cell death are complicated and not fully understood. It is expected that artificial and luminescent amphiphile drugs for the cell death induction of cancer cells would be powerful tools for not only anti-cancer drugs but also mechanistic analysis of their biological activity.