CONCENTRATIONS OF CHLORTETRACYCLINE IN FETAL TISSUES FOLLOWING ORAL ADMINISTRATION IN THE EWE

摘要

The objective of this study was to determine the disposition of chlortetracycline (CTC) in pregnant ewes and their unborn fetuses following oral administration of 500 mg/head/day during the last trimester of gestation.Five pregnant sheep were administered 500 mg of CTC in divided doses for 8 days. On day 7, the fetus was surgically implanted with venous lines for sampling, and placenta and amniotic fluid were harvested. Fetal plasma was sampled for 36 hours after thelast dose of CTC. Subsequently, ewes were sacrificed and samples of amniotic fluid, placenta, fetal kidneys, fetal liver, and fetal stomach contents were collected.