Comparison of Employing WI-38 and NIH/3T3 Cells for Evaluation of Chemotherapeutic Index and Growth Inhibition Values for Pancreatic Cancer Cell Lines for Group IVB Metallocene and Group VA Metal-Containing Polymers Derived from Glycyrrhetinic Acid, 3,5-Pyridine-dicarboxylic Acid, and Histamine

摘要

INTRODUCTION Pancreatic cancer afflicts close to 32,000 individuals each year in the United States and 168,000 worldwide, and nearly all patients die from the ravages of their disease within 3 to 6 months after detection. It is the fourth leading cause of cancer death worldwide behind lung (1.3 million deaths/year), stomach (1 million deaths/year), and liver (660,000 deaths/year). Treatment of pancreatic cancer is rarely successful as this disease typically metastasizes prior to detection. There is no chemotherapy for metastasized pancreatic cancer. More organotin compounds are available commercially than any other metal-containing organometallics.~(1,2) Further, more organotin compounds have undergone testing as potential anticancer agents than any other single group of compounds.