Spinal Cord Repair and Regeneration: The Application of Bioadhesives and Extracellular Matrix Bioscaffolds

摘要

Extracellular matrices (ECM) derived from urinary bladder membrane (UBM) have demonstrated substantial potential for applications in tissue repair and reconstruction. However, these materials are limited by the requirement of suturing following surgery. In this paper, the coalescence of UBM with an advanced surgical adhesive demonstrated a suitable alternative to sutures for wound closure, prevention of fluid leakage and improvement of cell growth. This novel bioadhesive contains favourable characteristics that are suitable for tissue repair, support of cell growth, and influence cellular microenvironments that are biocompatible with peripheral nerve regeneration in the spinal cord.