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Increased sensitization to Inhalant Allergens: A Review of Clinical Observations. Are Changes in the Environment Responsible?

机译:对吸入剂过敏原的致敏增加:临床观察的综述。 是负责环境的变化吗?

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Starting in 2012 unusual results were observed when performing skin allergy testing. Around that time the state of NJ was affected by severe storms: Hurricane Irene in 2011 and Hurricane Sandy in 2012. Review of tests results from before and after these storms revealed unexpected results. A random, retrospective allergy charts review was done, obtaining 2 groups of 100 patients each. Group A with charts from patients tested before the hurricanes and Group B with charts form patients tested after the storms. The information was evaluated by a statistician with the Chi-square test. Reactivity and sensitization to inhalant allergens increased compared to patients before the hurricanes. The patient pool consulting for allergic conditions after the storms appeared to have more severe disease. All results were found to be statistically significant. Changes observed after the storms included more positive skin testing results, many positive results were obtained with weaker allergen concentration, there was an overall increased level of reactivity to many more allergens. The post-hurricane population was younger and included more patients with asthma or lower respiratory symptoms. These findings support the hypothesis that environmental changes resulting from hurricanes can be a health risk as reflected by increased allergic sensitization and symptom-severity after the hurricanes. These results have significant clinical implications for physicians treating patients from affected areas.
机译:从2012年开始,在进行皮肤过敏测试时观察到异常结果。周围的时间,NJ的状态受到严重风暴的影响:2011年飓风Irene和2012年飓风桑迪。这些风暴之前和之后的测试结果审查了意外结果。随机,回顾性过敏图表进行了审查,完成了2组100名患者。 A组与患者在飓风和B组之前的患者进行图表,其中具有图表在暴风雨之后测试的患者。该信息由统计学家评估了Chi-Square测试。与飓风前的患者相比,对吸入剂过敏原的反应性和敏化增加。患者池咨询暴风雨后过敏条件患有更严重的疾病。发现所有结果都被发现是统计学意义的。在暴风雨中包括更高的皮肤测试结果后观察到的变化,通过较弱的过敏原浓度获得了许多阳性结果,对许多过敏原的反应性水平总体增加了。后飓风人口年轻,包括更多哮喘或呼吸症状的患者。这些调查结果支持假设,即飓风导致的环境变化可能是健康风险,反映在飓风后过敏性敏化和症状严重程度。这些结果对治疗受影响地区患者的医生具有显着的临床意义。

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