Brain Diffusion Tensor Imaging in Canine Degenerative Myelopathy

摘要

Canine degenerative myelopathy (DM) shares similarities with superoxide dismutase 1-associated human amyotrophic lateral sclerosis (ALS). Brain microstructural pathology has been quantified using diffusion tensor imaging (DTI) in ALS patients. Our objective was to use DTI to characterize neurodegenerative changes in the brain of DM dogs longitudinally and to determine the relationship to clinical severity.