Antipyretic Effects of (phaleria macrocarpa (scheff) boerl.) Infusa In Mice Galur Wistar As Animal Model

摘要

Objective: This study was conducted to prove the antipyretic effect of the (Phaleria Macrocarpa (Scheff) Boerl.) and the effect strength, because the scientific evidence and its benefits were still limited, although empirically its leaf has been widely used by society as antipyretics. Methods: Measurements were performed prior to condensation solution until after the solvent solution was performed at minute 0, 30, 60, 90, 120, and 180. The presence of antipyretic effect was indicated by a statistically significant different down temperature between the test groups and the positive control group. Statistical analysis using ANOVA (Analysis of Variance) and LSD (Least Significant Different) Test. Results: Results at concentrations of 3% showed a decrease in body temperature actively different against positive controls at 60, 120 and 180 (p <0.05), at a concentration of 6% showing a decrease in body temperature to positive controls at 120 and 180 minutes (P <0.05), whereas at a concentration of 12% showed a decrease in body temperature was actively different against positive controls at 30, 60, 120 and 180 (p <0.05). Conclusion: A 12% concentration showed the best antipyretic activity with the faster onset of action and the longest duration of action.