Effect of Amoxicillin and Clavulanic Acid Plus Prednisolone in the Reduction of Clinical Signs of Induced Mastitis

摘要

Antimicrobial therapy is the most common method to treat clinical mastitis in lactating cows. Intramammary syringes with antibiotics plus prednisolone are widely spread. The combination of 200 mg amoxicillin, 50 mg clavulanic acid and 10 mg prednisolone is the best-selling intramammary tube in a large number of European countries. Amoxicillin is a (J-lactam antibiotic and clavulanic acid inhibits beta-lactamases. Data from Germany showed a very high in vitro sensibility against this combination acidby the most relevant mastitis pathogens -including E. coli- (Leon et al., 2015). Prednisolone is an anti-inflammatory corticosteroid and we analyzed the effect of 10 mg prednisolone (internal reports 2847 and 1757/2) on reducing the clinical signs of mastitis after experimental inoculation with S. uberis or S. aureus.