Fabrication of BSA loaded Poly(Caprolactone) (PCL) Microsphere Incorporated Chitosan Scaffolds for Tissues Engineering Application

摘要

Scaffolds-based tissues engineering involves the combination of an artificial extracellular matrix (ECM), living cells, with high porosity and well connected pores that will provide suitable environment for cells. In this study, firstly, poly(caprolactone) (PCL)-based microspheres were synthesized and characterized. Bovine serum albumin (BSA) (0.04% w/v) was added into the microspheres produced from 5% (w/v) PCL concentration. BSA loaded microspheres were then incorporated into chitosan solution to fabricate porous scaffolds. The scaffolds were then characterized using different techniques.