Apoptosis induced by a novel Ruthenium II complex in a Gallbladder carcinoma cell line

摘要

Some metals with striking properties have been used for the development of different complexes with activity against malignant cells. Due to difficulties in early diagnosis of gallbladder cancer (GBC) the main treatment option is chemotherapy. In this line of research, ruthenium complexes represent a less toxic alternative that others metal complexes such as cis-platin. The aim of this study was to evaluate the effect of a novel ruthenium complex in activation of apoptosis in a cell lineG-415. Our results show an activity of inducing cell death and over-expression of pro-apoptotic transcripts.