Effects of Perilla frutescens Leaf Total Flavonoid on Enzyme of Lipoprotein Metabolism and Antioxidation in Hyperlipidemia Rats

摘要

To explore the effects of Perilla frutescens leaf total flavonoid (PFF) on regulating the serum level of lipids, enzymes of lipoprotein metabolism and antioxidation in the hyperlipidemia rats. 50 healthy SD rats were divided into 5 groups randomly according to the serum TC: hyperlipidemia model group, high dose group of PFF, medium dose group of PFF, low dose group of PFF, and lovastatin treatment positive control group. Serum lipoprotein level, lipoprotein lipase (LPL), hepatic lipase (HL), superoxide dismutase (SOD) and malondialdehyde (MDA) were tested after treated with corresponding drugs once per day for 4weeks. Compared with the model group, the levels of the serum TC, TG, LDL-C, and MDA decreased significantly, while HDL-C, LPL, HL and SOD increased significantly (P < 0.05 or P < 0.01). The lipid metabolic disorder in hyperlipidemia rats was improved notably through the treatment with PFF, indicating that the PFF plays an important role in decreasing lipids.