In models of young rats we studied influence of NOS inhibitors: 7-nitroindazol (7-NI), N~G-nitro-L-arginin-metyl ester (L-NAME) and PPAR gamma agonist pioglitazone (PIO) on blood pressure and radical signaling triggered via superoxide dismutases (SOD), and NO-synthases (NOS).From NOS inhibitors only L-NAME up-regulated blood pressure in young Wistar rats. However tissue specific modulation of AT1R, SOD1 and/or SOD3 genes was observed for both inhibitors. Decrease of blood pressure in young SHR after PIO treatment was joined with tissue specific effect of this substance. Antioxidant effects of PIO were in left ventricle realized through an increase of total SOD activities. Different responses at central and peripheral level should be clarified by further investigation.
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