A Smart Biological Signal-Responsive Focal Drug Delivery System for Treatment of Refractory Epilepsy

摘要

In this paper, we propose a new biological signal-responsive implantable device that triggers direct an anticonvulsive drug into the epileptogenic zone at electrographic seizure onset. We describe the high-performance seizure-onset detection algorithm, low-power circuit technique and focal drug delivery system. The implantable device is composed of a preamplifier, a signal processor, a seizure detector and a micropump. The device records high quality intracerebral electroencephalographic (icEEG) signals using high conductive electrodes and a low noise preamplifier. The recorded signal is processed continuously using low-power technique to detect onset of seizures accurately. The low-power miniaturized micropump is able to deliver sufficient amount of anticonvulsive drug in a short duration (50μL/sec) to epileptogenic zone. The detection algorithm was validated with Matlab tools and a prototype device was assembled with discrete components in a circular (? 40 mm) printed circuit board. The device was validated offline using the icEEG recordings obtained from 3 drug-resistant epilepsy patients. The average seizure detection delay was 10 sec from electrographic seizure onset, well before seizure progression to adjacent functional cortex.