DETECTION OF DNA AT THE MICROCHIP: Study of DNA Detection Microchip by Oxidation Peak of DNA

摘要

We have demonstrated the separation and detection of DNA on the microchip based on amperometric with capillary electrophoresis. To enhance analytic perfermance such as throughput and analysis time, electrophoretic separation of DNA in capillaries or on microchips has been investigated using various microchip structures. Compared with commonly used laser induced fluorescence method, this method is more compatible with microchip and offer improved portability and miniaturization. Through Cyclic voltammetric experimental, we could optimized detection voltage for detection of DNA. At the optimal detection voltage, DNA fragments were successfully separated and detected with high sensitivity and stable baseline.