Rehabilitation of allitridi on homocysteinemia induced injury of endothelin and nitrogen oxide in rats

摘要

The step-up level of serum homocysteine (Hcy) in blood is an independent risk factor for vascular disease, such as atherosclerosis. Low and moderate rise in Hcy can increase the death risk to patients with cardiovascular and cerebrovascular diseases by four to six times. In the development of coronary heart disease (CHD), relative risk of hyperhomocysteinemia is 23.9, which is far higher than other factors, such as hypertensive disease and hyperlipemia disease. Moreover, dysfunction of vascular endothelium caused by hyperhomocysteinemia is important initiatory elements in the pristine development of atherosclerosis. Thus, this study was designed to investigate the rehabilitation of allitridi on homocysteinemia induced injury of endothelin (ET) and nitrogen oxide (NO) in rats. Fifty Wistar male rats were randomly divided into 5 groups: large dose garlic group (GL group), small dose garlic group (GS group), homocysteine group (HC group), folic acid group (AC group), and control group (NC group). The homocysteinemia model was established in rats through feeding induce by high dose methionine forage. At the same time, the rats of GL group and GS group were separately given allitridi 10mg/kg and 6mg/kg with abdominal injection. The sixth weekend, the blood of all rats was collected to determine the Hcy, ET and NO. The results indicated that (1) The Hcy of HC group and AC group were significantly higher than that of GL group, GS group and NC group (P<0.05–0.01). (2) The ET and ET/NO ratio of GL group and GS group were significantly lower, the NO were significantly higher, than that of HC group (P<0.05–0.01). We conclude that (1) Allitridi can significantly decrease Hcy and ET, increase NO and recover ET/NO balance in the rats with homocysteinemia; (2) It can protect and cure homocysteinemia and atherosclerosis.