Evaluation of anti-diabetic activities of Hovenia dulcis Thunb

摘要

Hovenia dulcis Thunb, a food supplement and traditional medicine used in East Asia, has been demonstrated to exhibit hepatoprotective, antimicrobial, neuroprotective, and anti-oxidant activities. To evaluate the anti-oxidant activities of H. dulcis in STZ-induced diabetic mice, the different extracting solvents were employed to compare the antioxidant activity by the classical Fenton's reagent, the concentrations of SOD, MDA, and iNOS in the serum were determined. The results showed that the ethanol (70%) exhibited the most effective antioxidant activity and dose-dependently upregulation of SOD and down-regulation of MDA and iNOS significantly in STZ-induced diabetic mice. These indicated that H. dulcis displayed remarkable anti-diabetic activity.