Action of Valeriana jatamansi Jones on the Apoptosis-related Genes Expression in the Anxiety Model of Rat

摘要

Aims: To observe the apoptosis-related genes expression in the difference groups and the action of Valeriana jatamansi Jones. Methods: EPM was used to make the anxiety model of rat. The gene expression difference chart of apoptosis-related gene in normal rats, anxiety model rats and rats treated by the extract of Valeriana jatamansi Jones were examined by using the gene chip technology. Results.: Compared with normal group, the expression of Elk-1, Ets-1, Apaf-1, Bax and Bcl-2 were up-regulated in the model group. But the abnormal gene expression were adjusted in the other groups. Conclusion: The Valeriana jatamansi Jones can play a important role in regulating the abnormal apoptosis-related gene expression in the anxiety model of rat.