Intensive Care Managament of Acute Organophosphate Poisoning: Clinical Experience and the Review of the Literature

摘要

Current therapeutic scheme for management of acute poisoning with anticholinesterase pesticides includes general supportive measures (decontamination, respiratory support) and specific pharmacological treatment (atropine, oxime, diazepam). Antidote therapy is aimed to competitively antagonise overstimulation of muscarinic receptors with atropine and to reactivate inhibited AChE with oximes. Rectivation and clinical improvement of neuromuscular function are limited by aging of acetylcholinesterase and high concentrations of organophosphates. Results of our longitudinal clinical experience confirm benefitial effect of oxime administration in OP poisoning.