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Live Demonstration: HemeChip - A Portable Microchip Electrophoresis Technology for Point-of-Care Sickle Cell Disease Screening

机译:现场演示:Hemechip - 一种便携式微芯片电泳技术,用于护理点镰状细胞病筛选

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HemeChip is the first miniaturized, single-use cartridge-based microchip electrophoresis system for identifying and quantifying hemoglobin (Hb) variants from a drop of blood at the point-of-care (POC). It is estimated that 7% of world's population lives with a hemoglobin variant, and one of the most common and severe one being the recessively transmitted sickle hemoglobin which results in Sickle Cell Disease (SCD). HemeChip (Fig. 1A,C) separates Hb variants on a strip of cellulose acetate (CA) paper that is housed in the HemeChip cartridge. This HemeChip cartridge is a mass-producible, single-use cartridge that maintains a controlled environment and a constant electric field (applied through the electrodes, Fig. 1B) for the Hb separation process. The cartridge also contains an in-chip blotting mechanism and an anti-fogging feature. The anti-fogging feature is essential for real-time imaging and tracking of Hb band(s) during the separation process. HemeChip is integrated with a portable reader (Fig. 1D) to detect the type(s) and fraction of hemoglobin types present in a blood sample. HemeChip technology has been designed and developed to offer a robust, user-friendly platform to detect, identify, and quantify Hb variants (responsible for SCD variants) even in a limited resource settings.
机译:Hemechip是第一种小型化的单用盒式微芯片电泳系统,用于识别和量化来自护理点(POC)的血液中的血红蛋白(HB)变体。据估计,世界上7%的人口含有血红蛋白变异,以及最常见的和严重的一种是具有隐性传播的镰刀血红蛋白,这导致镰状细胞疾病(SCD)。 Hemechip(图1A,C)将容纳在Hemechip盒中的醋酸纤维素(CA)纸的条带上分离Hb变体。该Hemechip盒是一种质量生产的单用盒,其维持受控环境和恒定的电场(通过电极施加的电极,图1B),用于HB分离过程。墨盒还包含片上印迹机构和防雾特征。防雾功能对于分离过程中的HB频带的实时成像和跟踪是必不可少的。 Hemechip与便携式读取器(图1D)集成在血液样本中检测存在于存在的血红蛋白类型的类型和分数。 Hemechip技术已经设计和开发,提供强大的用户友好的平台,即使在有限的资源设置中,也可以检测,识别和量化HB变体(对SCD变体负责)。

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