Preparation and In Vivo Study of an Anti-infective Highly Volatile Wound Dressing Material

摘要

In this research, a highly volatile membrane forming solution of gelatin with quick membrane forming property (30 sec) was prepared to investigate the suitability of solution spray system in the treatment of wound at dermal surface. A nontoxic Aromatic Ketone (AK) and a highly volatile solvent (VS) were introduced in gelatin solution to ensure high volatility. The solution was subjected to antibiotic dosing using Ciprofloxacin to ensure its anti-infectiveness. The pH of the raw gelatin solution and the highly volatile gelatin solution were 4.95 and 6.17 respectively. Viscosity of gelatin/AK/VS solution was 62.12mPa.s. Wound healing characteristic of the highly volatile solution (gelatin/AK/VS) was evaluated using a rat (Rattus norvegicus) model. Full-thickness wounds were created on the ventral side of the Rattus norvegicus and were dressed with the volatile solution and "eco-plaster" (control). Wound healing and bioadhesion were monitored in 3-days interval. The results revealed that prepared volatile solution was more effective in preventing blood loss as well as healing wounds than the conventional wound dresser.