Immunologic Signs of Fibrous Changes Debut in the Liver of Patients with Chronic Hepatitis B

摘要

There are some problems of registration of liver fibrosis initial changes in patients with chronic hepatitis B. The authors stated that criteria indices of the immune state connected with the possibility to prognose debut of liver fibrous changes can be quantitative characteristics of content in blood of monocytes, T cell subsets, especially with cytotoxic activity (CD3+/CD8+), NKT (CD3+/CD56+) and their subpopulations (CD4+, CD8+, DN), some indices of functional state of natural killer cells. All these indices in defined range values comprise the unique criteria complex of fibrous changes start in the liver of chronic hepatitis B patients and spillover of criteria range values (while monitoring of the disease) means active progress of fibrosis process.