Self-Assembled Iron Oxide Core for the Synthesis of an Intrinsic Quick-Magnetophoretic Core-Shell Superparamagnetic Nanoparticles and their in vivo Study

摘要

@@A magnetically-induced targeted delivery of drug or gene is an interesting method to enhance the drug enrichment at the target site and bioavailability and to reduce the side effect or toxicity of the drug or gene with the help of an external magnetic field [1-3]. Magnetic nanoparticles, composed of a magnetic component (e.g. iron oxide/magnetite) and a biocompatible component (e.g. dextran, starch), offer a potential method for tumor drug delivery with benefits that extend beyond the enhanced permeation retention (EPR) effect. These additional advantages originate from such specific properties of magnetic nanoparticles as magnetic responsiveness and MRI visibility [4]. Obviously it is always attracting and expected for the above goal to design such a nanoparticle with high-magnetophoretic mobility, or a strong response to an external magnet field.