Effect of subacute ruminal acidosis on mRNA expressions of hypothalamic appetite regulated factors

摘要

Introduction Feeding high concentrate diets induced subacute ruminal acidosis (SARA).SARA occurs often accompany with food intake depression.But the mechanism of this depression in central brain is lacking.Results of Real-time PCR were that,compared with the control group,mRNA expression of hypothalamic agouti-related protein (AgRP) was significantly decreased (P＜0.05),and neuropeptide Y (NPY) mRNA expression showed a tendency to decrease (P=0.052) in the goats of the SARA group.However,no significant differences of pro-opiomelanocortin (POMC) or melanocortin receptor 4 (MCR4) in hypothalamus were observed between two groups.The depression of food intake of SARA goats was associated with the down-regnlatedmRNA expressions of AgRP and NPY in hypothalamus in our study.