Study on the Change of Serum IGF-1, GABA and GLU of Cerebral Palsy

摘要

BACKGROUND: In the past few years, there was much study about the pathophysiology of insulin-like growth factor-1 (IGF-1), as well as glutamic acid (GLU) and y-aminobutyric acid (GABA) in hypoxic-ischemic brain damage (HIBD). IGF-1 plays a protective role in brain damage. The over release of excitatory amino acids (EAA) plays an important role in acute neuronal death, which delays neuronal death. The disproportion of increasing of excitatory and inhibitory amino acids can cause different extent HIBD. However, there is rare report about the change of IGF-1 and neurotransmitter level in serum of cerebral palsy (CP) children. OBJECTIVE: To observe the levels of serum IGF-1, GABA and GLU before and after functional exercise plus head acupuncture therapy and single functional exercise, then study the effective mechanism of IGF-1, GABA and GLU in the occurrence and development of CP, and compare those with normal control group. DESIGN: Case-control study. SETTING: College of Rehabilitation Medicine of Jiamusi University; Prevention and Treatment Center of Child Cerebral Palsy in Heilongjiang Province (Child nerves Rehabilitation Laboratory of Jiamusi University). PARTICIPANTS: CP group: Sixty CP children came from Prevention and Treatment Center of Child Cerebral Palsy in Heilongjiang Province between April 2005 and March 2006 were selected in this study. All the cases were consistent with the diagnostic criteria and the type of cerebral palsy and finally diagnosed with CT and MRI examinations.