Regulation of mitochondrial and tissue oxidations by thyroid hormones in chicken muscle

摘要

Thyroid hormones are major hormones regulating development and energy expenditure in mammals and in avian species (Decuypere et al., 1981; Silva, 1995). They modulate transcription of target genes by interacting with intracellular thyroid receptors that bind to thyroid hormone response elements (TRE) located on DNA. They can also act as direct stimulators of enzymes involved in the respiratory machinery (Goglia et al., 1999). In mammals, thyroid hormones are also shown to regulate fatty acid utilisation (Lanni et al., 2005). As in mammals, oxidative pathways might be affected by thyroid status in the chicken. The aim of this study was therefore to investigate the impact of thyroid hormones on the expression of genes involved in energy substrate utilisation and on oxidative stress in the chicken Gastrocnemius muscle.