Bioreactive Nnanostructured Sol-Gel-Derived Titanium Oxide Coatings

摘要

The ideal nanostructured materials for biomedical application are those that can enhance normal wound healing, prevent non-specific protein adsorption, produce an interfacial matrix that is similar to the host in composition, reduce the stresses at the implant/host interfaces, or have adequate biomechanical properties. In other words, these materials should be able to perform with an appropriate host response in a specific application. Titanium and its alloys are excellent biomaterials because of their surface reactive oxide. Nanostructured multilayer organization of this oxide with biologically relevant molecules to enhance bioreactivity or prevent nonspecific protein adsorption is a major area of intensive study. Surface sol-gel processing (SSP) is a stepwise solution-gelation process to form nanometer- thick oxide films1. It is a potential modification technique to produce nanostructured titanium oxide applicable to various biomedical applications. SSP is readily applied to any hydroxylated surface using a metal alkoxide reactive to OH groups, and the sol-gel procedure is independent of each cycle, which allows individual layers to be nanostructured1. We investigated the bioreactivity of sol-gel derived titanium oxide modified with chitosan, adhesive Arg-Gly-Asp (RGD) peptides and polyethylene glycol.