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In Vitro Skin Irritation Assays: Relevance to Human Skin

机译:体外皮肤刺激测定:与人体皮肤的相关性

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摘要

The events occurring in primary skin irritation in vivo represent a complex series of chemical and physiological changes. Animals have been used to assess dermal irritation by observation of visible changes ranging from erythema and edema to corrosion and ulceration in the in vivo Draize rabbit skin test accepted by many regulatory agencies [Draize et al., 1944]. These responses, easily observed, are produced by diverse mechanisms.
机译:体内初级皮肤刺激发生的事件代​​表了复杂的化学和生理变化。通过观察来自红斑和水肿的可见变化来评估真皮刺激,从红斑和水肿中的腐蚀和溃疡展示了许多监管机构所接受的体内恐慌和溃疡[Draize等,1944]。通过多样化的机制,易于观察到这些响应。

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