Natural Products and TSielr Role in the Design of Active Ingredients for Modern Crop Protection

摘要

Today only a few natural products are directly used as acti ve ingredients within the current main areas of modern crop protection. However, the influence of synthetic commercial agrochemicals having a natural origin is remarkable for the total insecticide and fungicide market. The successful utili zation of natural products and their role as lead structures in the design of synthetic analogues as active ingredients is exemplified with commercial products from Bayer Crop Science. The molecular diversity of natural products plays a dominant role in the discovery process and has opened up new approaches for lead-finding as well. The dereplication process, novel and complementary technologies and scree ning methods for a high number of compounds are a power ful tool in the search for hitherto unknown compounds.