Production of Vaccines and Therapeutics in Plants for Oral Delivery

摘要

With in the last decade there has been enormous advancement in the utilization of transgenic plants or plant-derived products for mucosal delivery of vaccine and therapeutic proteins to the gastrointestinal tract. This review focuses on the unique aspects of mucosal immune system as it relates to mucosal delivery of vaccines or therapeutics using plants as edible dietary delivery systems. Edible plant delivery systems are attractive because they are safe, inexpensive, and easy to administer. However, in order to be efficacious they must survive the adverse environment of the stomach and be formulated to induce the appropriate immunological response of immunity or tolerance.