Physiological study of the effect astaxanthin (shrimp extract) on some biochemical markers in male rats induced by formaldehyde

摘要

Background and objectives: The present study was conducted to show the protective and treated effects of astaxanthin in male rats induced by formaldehyde. Materials and Methods: The total numbers of male rats include ninety one (91) males, weighing (190-300) mg, aged (15-17) weeks. The animals were housed in animal house of college of science / University of Kufa from period February 2018 to July 2018. The animal were divided into two groups protective group total male rats were (36) and treated group (55) male rats. Results: the result sowed a significant increase (p < 0.05) in AST, ALT and ALP level in formaldehyde group whene compared with control group and significant decrease (p < 0.05) in protective and treated groups of astaxanthin 250 and 500 mg/kg as compared with control group and formaldehyde groups. The study of biomarkers also showed a significant increase (p < 0.05) in Regucalcin, 8-hydroxy -2 deoxyguanosine and Myeloperoxidase level in formaldehyde group as compared with control group and showed a significant decrease (p < 0.05) in all biomarkers when compared of astaxanthin & formaldehyde with formaldehyde group and non-significant difference (p < 0.05) when compared with control group. Conclusion: The present study roles of Astaxanthin as protective and treatment were documented by decrement in liver enzyme AST,ALT and ALP also Creatinine after increment by formaldehyde.