Development of a Polypyrrole-Modified Graphite Electrode for Acetaminophen Determination

摘要

Nowadays, acetaminophen (commonly known as paracetamol), has been one of the most used drugs for pain treatment. By now, there have been reported only two official methods for the determination of this pharmaceutical active: HPLC and direct titration. Other techniques have been also reported in literature, like: spectroscopy, capillary electrophoresis and electrochemical techniques, including biosensors, microelectrodes and modified electrodes, these last have additional advantages like economy, fast and reliable response, and high selective to acetaminophen. In the present work an electroanalytical low-cost technique is proposed for the selective quantification of acetaminophen determination. This selectivity is achieved by molecular imprinting of acetaminophen on a polypyrrole matrix, electrochemically synthetized on the surface of a graphite electrode. The polypyrrole matrix acts as a selective preconcentration material for acetaminophen that is latter determined by Square Wave Voltammetry in a separate clean electrolyte.