SULFONE-BASED GALECTIN-3 INHIBITORS TO TARGET A NEW POCKET NEAR THE CANONICAL CRD

摘要

The overall goal of the present project is to synthesize galectin ligands to allow for detailed biophysical characterization of galectin-ligand interactions. A key feature of galectins is binding affinity towards galactoside-containing glycoconjugates [1]. Natural small ligand fragments of the galectins, such as N-acetyl lactosamine (LacNAc) and lactose, show low inhibition potency why detailed biophysical characterization of galectin ligand recognition is imperative to facilitate denovo ligand design.