SYNTHESIS OF C-GLYCOSYL POLYPHENOLS AND STD-NMR INTERACTION STUDIES WITH AN AMYLOID POLIPEPTIDE

摘要

Polyphenols have shown numerous biological activities and health benefits for treatment of diabetes and Alzheimer's including the capacity to inhibit the accumulation of ss-amyloid fibrils [1-2]. Previous work in our group has disclosed a C-glucosyl flavonoid to interact with amyloid oligomers preventing aggregates formation [3].